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Update Excimerlaserchirurgie (Seite 10-14)
Stefanie Schmickler

  1. Zhang ZH et al. Femtosecond laser versus mechanical microkeratome laser in situ keratomileusis for myopia: Metaanalysis of randomized controlled trials. J Cataract efract Surg. 2011 Dec;37(12): 2151-9.
  2. Chen S et al. IntraLase femtosecond laser vs mechanical microkeratomes in LASIK for myopia: a systematic review and meta-analysis. J.Refract Surg.2012 Jan;28(1):15-24.
  3. Jun I, Kang DSY, Reinstein DZ, Arba-Mosquera S, Archer TJ, Seo KY, Kim TI. Clinical Outcomes of SMILE With a Triple Centration Technique and Corneal Wavefront-Guided Transepithelial PRK in High Astigmatism. J Refract Surg. 2018 Mar 1;34(3):156-163
  4. Camellin M, Arba Mosquera S. Simultaneous aspheric wavefront-guided transepithelial photorefractive keratectomy and phototherapeutic keratectomy to correct aberrations and refractive errors after corneal surgery. J Cataract Refract Surg; 2010; 36: 1173-1180
  5. Aslanides IM, Padroni S, Mosquera SA, Ioannides A, Mukherjee A. Comparison of single-step reverse transepithelial all-surface laser ablation (ASLA) to alcohol-assisted photorefractive keratectomy. Clinical Ophthalmology 2012 June;6(1):973-980
  6. Arba Mosquera S, Awwad ST. Theoretical analyses of the refractive implications of trans-epithelial PRK ablations. Br J Ophthalmol 2013;97:905-911
  7. Adib-Moghaddam S, Arba-Mosquera S, Salmanian B, Omidvari AH, Noorizadeh F. On-line pachymetry outcome of ablation in aberration free mode TransPRK. Eur J Ophthalmol. 2014 Jul-Aug;24(4):483-9
  8. Adib-Moghaddam S, Arba-Mosquera S, Walter-Fincke R, Soleyman-Jahi S, Adili-Aghdam F. Transepithelial Photorefractive Keratectomy for Hyperopia: A 12-Month Bicentral Study. J Refract Surg. 2016 Mar 1;32(3):172-80
  9. Vinciguerra P, Camesasca FI, Vinciguerra R, Arba-Mosquera S, Torres I, Morenghi E, Randleman JB. Advanced Surface Ablation with a New Software for the Reduction of Ablation Irregularities. J Refract Surg. 2017 Feb 1;33(2):89-95
  10. Adib-Moghaddam S, Soleyman-Jahi S, Adili-Aghdam F, Arba Mosquera S, Hoorshad N, Tofighi S.  Single-step transepithelial photorefractive keratectomy in high myopia: qualitative and quantitative visual functions. Int J Ophthalmol. 2017 Mar 18;10(3):445-452
  11. Lin DTC, Holland SP, Verma S, Hogden J, Arba-Mosquera S. Postoperative Corneal Asphericity in Low, Moderate, and High Myopic Eyes After Transepithelial PRK Using a New Pulse Allocation. J Refract Surg. 2017;33(12):820-826
  12. Lee H, Yong Kang DS, Reinstein DZ, Arba-Mosquera S, Kim EK, Seo KY, Kim TI. Comparing corneal higher-order aberrations in corneal wavefront-guided transepithelial photorefractive keratectomy versus small-incision lenticule extraction. J Cataract Refract Surg. 2018 May 19. pii: S0886-3350(18)30335-3.

Neues aus dem Homburger Keratokonuscenter HKC (Seite 15-21)
Berthold Seitz, Corinna Spira-Eppig, Loay Daas, Elena Zemova, Sonja Razafimino, Elias Flockerzi, Loic Hamon, Tanja Stachon, Nóra Szentmáry, Achim Langenbucher, Timo Eppig

  1. Goebels S, Seitz B, Langenbucher A: Diagnostik und stadiengerechte Therapie des Keratokonus – Eine Einführung in das Homburger Keratoconuscenter (HKC). Ophthalmologe 2013; 110:808-809
  2. Goebels S, Eppig T, Wagenpfeil S, Cayless A, Seitz B, Langenbucher A: Staging of keratoconus indices regarding tomography, topography and biomechanical measurements. Am J Ophthalmol  2015; 159:733-738
  3. Goebels S, Eppig T, Seitz B, Langenbucher A: Früherkennung des Keratokonus – Systemassistierte Screeningverfahren heute. Klin Monatsbl Augenheilkd 2013; 230:998-1004
  4. Weiss JS, Møller H, Aldave AJ, Seitz B, Bredrup C, Kivelä T, Munier FL, Rapuano CJ, Nischal K, Kim EK, Sutphin J, Busin M, Labbè A, Kenyon KR, Kinoshita S, Lisch W: IC3D classification of the corneal dystrophies  -  Edition 2. Cornea 2015; 34:117-159
  5. Spira C, Grigoryan A, Szentmáry N, Seitz B, Langenbucher A, Eppig T: Vergleich der Spezifität und Sensitivität verschiedener gerätegestützter Keratokonus-Indizes und Klassifikatoren. Ophthalmologe  2015; 112:353-358
  6. Goebels S, Eppig T, Wagenpfeil S, Cayless A, Seitz B, Langenbucher A: Complementary keratoconus indices based on topographical interpretation of biomechanical wave form parameters – a supplement to established keratoconus indices. Comput Math Methods Med 2017; 2017:5293573 
  7. Hanet MS, Zimpfer A, Lepper S, Seitz B:  Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis. J Ophthalmic Inflamm Infect 2018 Mar 7;8(1):4
  8. Stachon T, Kolev K, Flaskó Z, Seitz B, Langenbucher A, Szentmáry N: Arginase activity, urea concentration and hydroxyproline secretion are reduced in keratoconus keratocytes. Graefes Arch Clin Exp Ophthalmol 2017; 255:91-97
  9. Stachon T, Stachon A, Hartmann U, Seitz B, Langenbucher A, Szentmáry N: Urea, uric acid, prolactin and fT4 concentrations in aqueous humor of keratoconus patients. Curr Eye Research 2017; 42:842-846
  10. Song X, Gatzioufas Z, Wang J, Stachon T, Szentmáry N, Saw V, Langenbucher A, Seitz B: Effects of thyroxine and hydrocortisone on normal human keratocytes and keratoconic keratocytes in vitro.  Int J Clin ExpMed 2016; 9(9):17461-17474
  11. Thanos S, Oellers P, Meyer zu Hörste M, Prokosch V, Schlatt S, Seitz B, Gatzioufas Z: The role of thyroxine in the development  of keratoconus. Cornea 2016; 35:1338-1346
  12. Goebels S, Eppig T, Seitz B, Langenbucher A: Keratokonusprogression im Seitenvergleich. Klin Monatsbl Augenheilkd 2017; 234:1010-1014
  13. Eppig T, Spira-Eppig C, Langenbucher A, Seitz B. Biomechanik der Hornhaut als neuer Parameter in der Keratokonusdiagnostik? Concept Ophthalmologie 2017; (9):24-28
  14. Ambrosio R Jr, Lopes BT, Faria-Correia F, Salomão MQ, Bühren J, Roberts CJ, Elsheikh A, Vinciguerra R, Vinciguerra P: Integration of Scheimpflug-based corneal tomography and biomechanical assessments for enhancing ectasia detection.  J Refract Surg 2017; 33:434-443 
  15. Labiris G, Gatzioufas Z, Sideroudi H, Giarmoukakis A, Kozobolis V, Seitz B: Biochmechanical diagnosis of keratoconus: evaluation of the keratoconus match index and the keratoconus match probability. Acta Ophthalmol 2013; 91:e258-262
  16. Labiris G, Giarmoukakis A, Sideroudi H, Song X, Kozobolis V, Seitz B, Gatzioufas Z: Diagnostic capacity of biomechanical indices from a dynamic bidirectional applanation device in pellucid  marginal degeneration. J Cataract Refract Surg 2014; 40:1006-1012
  17. Belin MW, Duncan JK:  Keratoconus: The ABCD Grading System. Klin Monatsbl Augenheilkd 2016; 233:701-707
  18. Eppig T, Spira-Eppig C, Goebels S, El-Husseiny M, Lenhart M, Papavasileiou K, Szentmáry N, Seitz B, Langenbucher A: Asymmetry between left and right eye in keratoconus increases with the severity of the worse eye. Curr Eye Res 2018; 43:848-855
  19. Goebels S, Käsmann-Kellner B, Eppig T, Seitz B, Langenbucher A: Can retinoscopy keep up in keratoconus diagnosis?  Cont Lens Anterior Eye  2015; 38:234-239 
  20. Goebels S, Eppig T, Seitz B, Szentmáry N, Cayless A, Langenbucher A: Endothelial alterations in 712 keratoconus patients – A report of the Homburg Keratoconus Center HKC. Acta Ophthalmologica 2018;  96(2):e134-e139
  21. Klühspies U, Grunder A, Goebels S, Schirra F, Seitz B: Keratokonuslinse - Das kleine Korrektionswunder. Ophthalmologe 2013; 110:830-883
  22. El-Husseiny M, Tsintarakis T, Eppig T, Seitz B: Intrakorneale Ringsegmente beim Keratokonus. Ophthalmologe 2013; 110:823-829
  23. El-Husseiny M, Daas L, Langenbucher A, Seitz B: Intrakorneale Ringsegmente bei Keratektasien – Zwischenergebnisse und potentielle Komplikationen. Klin Monatsbl Augenheilkd 2016; 233:722-726
  24. Seitz B, Szentmáry N, El-Husseiny M, Viestenz A, Langenbucher A, Naumann GOH: The penetrating keratoplasty (PKP) – A century of success. In: Hjortdal J (ed): Corneal Transplantation. Springer International Publishing Switzerland, 2016, S. 67-92 (available at link.springer.com/book/10.1007%2F978-3-319-24052-7). 
  25. Yi L, Seitz B, Langenbucher A, Nguyen NX, Naumann GOH: Impact of preoperative corneal curvature on the outcome of penetrating keratoplasty in keratoconus. Cornea 2003; 22:409-412
  26. Langenbucher A, Neumann J, Kus MM, Seitz B: Berechnung von Lokalisation und Dimension der reellen Pupille bei Keratokonus mittels Raytracing von Hornhauttopographiedaten. Klin Monatsbl Augenheilkd  1999; 215:163-168
  27. Seitz B, Szentmáry N, Langenbucher A, Hager T, Viestenz Ar, Janunts E, El-Husseiny M: Perforierende Keratoplastik bei fortgeschrittenem Keratokonus – vom Hand/-Motortrepan zum Excimerlaser und zurück zum Femtosekundenlaser. Klin Monatsbl Augenheilkd 2016; 233:727-736 
  28. El-Husseiny M, Seitz B, Langenbucher A, Akhmedova E, Szentmary N, Hager T, Tsintarakis T, Janunts E:  Excimer vs. femtosecond laser assisted penetrating keratoplasty in keratoconus and Fuchs dystrophy: intraoperative pitfalls. J Ophthalmol  Volume 2015 (2015), Article ID 645830
  29. Seitz B, Langenbucher A, Hager T, Janunts E, El-Husseiny M, Szentmáry N: Penetrating keratoplasty for keratoconus - excimer versus femtosecond laser trephination. Open Ophthalmol J 2017 Jul 31;11:225-240
  30. Seitz B, Cursiefen C, El-Husseiny M, Viestenz A, Langenbucher A, Szentmáry N: DALK und perforierende Laserkeratoplastik bei fortgeschrittenem Keratokonus. Ophthalmologe 2013; 110:839-848
  31. Anwar M, Teichmann KD: Big-bubble technique to bare Descemet’s membrane in anterior lamellar keratoplasty.  J Cataract Refract Surg 2002; 28:398-403
  32. Flockerzi E, Maier P, Böhringer D, Reinshagen H, Kruse F, Cursiefen C, Reinhard T, Geerling G, Torun N, Seitz B, all German Keratoplasty Registry Contributors: Trends in corneal transplantation from 2001 to 2016 in Germany  -  A report of the Section DOG-Cornea and its Keratoplasty Registry. Am J Ophthalmol 2018; 188:91-98 
  33. Yahia Chérif H, Gueudry J, Afriat M, Delcampe A, Attal P, Gross H, Muraine M: Efficacy and safety of pre-Descemet's membrane sutures for the management of acute corneal hydrops in keratoconus. Br J Ophthalmol 2015; 99:773-777

Der theoretische Effekt der Einbeziehung der Spenderradien auf den postoperativen Hornhautastigmatismus (Seite 22-25)
Jörg H. Krumeich, Alfred Knülle-Wenzel

  1. Read, S., Collins, M., Carney, L. A review of astigmatism and its possible genesis. Clin Exp Optom 2007; 90: 1:5-19
  2. Krumeich, J., Binder, P., Knülle, A. The theoretical effect of trephine tilt on postkeratoplasty astigmatism. Send to CLAO J. 1988 Oct-Dec;14(4):213-9.
  3. Seitz, B., Langenbucher, A., Naumann, G. Trephination in Penetrating Keratoplasty. In: Krieglstein, G., Weinreb, R. Corneal and External Eye Disease. Springer: 2006.
  4. Belmont SC1, Zimm JL, Storch RL, Draga A, Troutman RC. Astigmatism after penetrating keratoplasty using the Krumeich guided trephine system. Refract Corneal Surg. 1993 Jul-Aug;9(4):250-4.
  5. Krumeich JH1, Duncker G. Intrastromal corneal ring in penetrating keratoplasty: evidence-based update 4 years after implantation. J Cataract Refract Surg. 2006 Jun;32(6):993-8.

Optimierung der DMEK – Erfahrung aus über 2000 Operationen (Seite 26-29)
Mario Matthaei, Björn Bachmann, Sebastian Siebelmann, Claus Cursiefen

  1. Zirm E (1906) Eine erfolgreiche totale Keratoplastik. Albr von Græfe’s Arch für Ophthalmol 54:580-593
  2. Terry MA, Ousley PJ (2001) Deep lamellar endothelial keratoplasty in the first United States patients: early clinical results. Cornea 20 (3):239-243
  3. Melles GR, Wijdh RH, Nieuwendaal CP (2004) A technique to excise the descemet membrane from a recipient cornea (descemetorhexis). Cornea 23 (3):286-288
  4. Price FW, Jr., Price MO (2005) Descemet's stripping with endothelial keratoplasty in 50 eyes: a refractive neutral corneal transplant. Journal of refractive surgery 21 (4):339-345
  5. Melles GRJ, Ong TS, Ververs B, van der Wees J (2006) Descemet membrane endothelial keratoplasty (DMEK). Cornea 25 (8):987-990
  6. Matthaei M, Bachmann B, Siebelmann S, Cursiefen C (2018) [Technique of Descemet membrane endothelial keratoplasty (DMEK) : Video article]. Ophthalmologe. doi:10.1007/s00347-018-0743-8
  7. Cursiefen C, Kruse FE (2010) [DMEK: Descemet membrane endothelial keratoplasty]. Ophthalmologe 107 (4):370-376. doi:10.1007/s00347-010-2155-2
  8. Flockerzi E, Maier P, Böhringer D, Reinshagen H, Kruse FE, Cursiefen C, Reinhard T, Geerling G, Torun N, Seitz B (2018) Trends in corneal transplantation from 2001 to 2016 in Germany: A report of the DOG-Section Cornea and its Keratoplasty Registry. Am J Ophthalmol. doi:10.1016/ j.ajo.2018.01.018.
  9. Steven P, Le Blanc C, Velten K, Lankenau E, Krug M, Oelckers S, Heindl LM, Gehlsen U, Huttmann G, Cursiefen C (2013) Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography. JAMA ophthalmology 131 (9):1135-1142
  10. Siebelmann S, Bachmann B, Lappas A, Dietlein T, Hermann M, Roters S, Cursiefen C, Steven P (2016) [Intraoperative optical coherence tomography in corneal and glaucoma surgical procedures]. Intraoperative optische Koharenztomographie bei hornhaut- und glaukomchirurgischen Eingriffen. Ophthalmologe 113 (8):646-650
  11. Siebelmann S, Hermann M, Dietlein T, Bachmann B, Steven P, Cursiefen C (2015) Intraoperative Optical Coherence Tomography in Children with Anterior Segment Anomalies. Ophthalmology 122 (12):2582-2584. doi:10.1016/j.ophtha.2015.06.004
  12. Bachmann BO, Schrittenlocher SA, Schaub F, Siebelmann S, Matthaei M, Cursiefen C (2017) [Complications of DMEKeratoplasty: Avoid, Recognize and Treat]. Klin Monbl Augenheilkd 234 (11):1354-1361. doi:10.1055/s-0043-105269
  13. Schaub F, Enders P, Zachewicz J, Heindl LM, Stanzel TP, Cursiefen C, Bachmann BO (2016) Impact of Donor Age on Descemet Membrane Endothelial Keratoplasty Outcome: Evaluation of Donors Aged 17-55 Years. Am J Ophthalmol 170:119-127. doi:10.1016/j.ajo.2016.08.005
  14. Schaub F, Pohl L, Enders P, Adler W, Bachmann BO, Cursiefen C, Heindl LM (2017) Impact of corneal donor lens status on two-year course and outcome of Descemet membrane endothelial keratoplasty (DMEK). Graefes Arch Clin Exp Ophthalmol 255 (12):2407-2414. doi:10.1007/s00417-017-3827-2
  15. Kruse FE, Laaser K, Cursiefen C, Heindl LM, Schlotzer-Schrehardt U, Riss S, Bachmann BO (2011) A stepwise approach to donor preparation and insertion increases safety and outcome of Descemet membrane endothelial keratoplasty. Cornea 30 (5):580-587
  16. Bachmann BO, Laaser K, Cursiefen C, Kruse FE (2010) A method to confirm correct orientation of descemet membrane during descemet membrane endothelial keratoplasty. Am J Ophthalmol 149 (6):922-925 e922. doi:10.1016/j.ajo.2010.01.005
  17. Dapena I, Moutsouris K, Droutsas K, Ham L, van Dijk K, Melles GRJ (2011) Standardized "no-touch" technique for descemet membrane endothelial keratoplasty. Archives of ophthalmology (Chicago, Ill : 1960) 129 (1):88-94
  18. Schrittenlocher S, Schaub F, Hos D, Siebelmann S, Cursiefen C, Bachmann B (2018) Evolution of Consecutive Descemet Membrane Endothelial Keratoplasty Outcomes Throughout a 5-Year Period Performed by Two Experienced Surgeons. Am J Ophthalmol 190:171-178. doi:10.1016/j.ajo.2018.03.036
  19. Siebelmann S, Lopez Ramos S, Scholz P, Matthaei M, Schrittenlocher S, Heindl LM, Bachmann B, Cursiefen C (2018) Graft Detachment Pattern After Descemet Membrane Endothelial Keratoplasty Comparing Air Versus 20% SF6 Tamponade. Cornea. doi:10.1097/ICO.0000000000001597
  20. Schaub F, Simons HG, Roters S, Heindl LM, Kugler W, Bachmann BO, Cursiefen C (2016) [Influence of 20% sulfur hexafluoride (SF6) on human corneal endothelial cells : An in vitro study]. Einfluss von 20% Schwefelhexafluorid (SF6) auf humane korneale Endothelzellen : Eine In-vitro-Studie. Ophthalmologe 113 (1):52-57
  21. Stanzel TP, Ersoy L, Sansanayudh W, Felsch M, Dietlein T, Bachmann B, Cursiefen C (2016) Immediate Postoperative Intraocular Pressure Changes After Anterior Chamber Air Fill in Descemet Membrane Endothelial Keratoplasty. Cornea 35 (1):14-19. doi:10.1097/ICO.0000000000000669
  22. Hos D, Tuac O, Schaub F, Stanzel TP, Schrittenlocher S, Hellmich M, Bachmann BO, Cursiefen C (2017) Incidence and Clinical Course of Immune Reactions after Descemet Membrane Endothelial Keratoplasty: Retrospective Analysis of 1000 Consecutive Eyes. Ophthalmology 124 (4):512-518. doi:10.1016/j.ophtha.2016.12.017
  23. Hoerster R, Stanzel TP, Bachmann BO, Siebelmann S, Felsch M, Cursiefen C (2016) Intensified Topical Steroids as Prophylaxis for Macular Edema After Posterior Lamellar Keratoplasty Combined With Cataract Surgery. American journal of ophthalmology 163:174-179.e172
  24. Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, Tanaka H, Yamamoto Y, Nakamura T, Inatomi T, Bush J, Toda M, Hagiya M, Yokota I, Teramukai S, Sotozono C, Hamuro J (2018) Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy. N Engl J Med 378 (11):995-1003. doi:10.1056/NEJMoa1712770
  25. Iovieno A, Neri A, Soldani AM, Adani C, Fontana L (2017) Descemetorhexis Without Graft Placement for the Treatment of Fuchs Endothelial Dystrophy: Preliminary Results and Review of the Literature. Cornea 36 (6):637-641
    Myopie und Müller`sche Stützzelle (Seite 30-31)
    Peter Heilig
  1. Franze K et al (2007) Müller cells are living optical fibers in the vertebrate retina. PNAS104 (20): 8287-8292
  2. Mani A, Schwartz GW ( 2017) Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites. Curr Biol.  20;27(4):471- 482.
  3. Detwiler PB (2018) Phototransduction in Retinal Ganglion Cells. Yale J Biol Med. 91(1): 49–52.
  4. Paylakhi S et al (2018) Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. PLOS. doi.org/10.1371/journal.pgen.1007244
  5. Heilig P (2017) Mini-Traumata, diverse. Concept Ophthalmologie 8, 28-29
  6. Heilig P Kunstlicht in unseren Augen www.youtube.com/watch