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Literatur:

Systemtherapie beim Mammakarzinom

Nadia Harbeck (S. 10)

 

  1. AGO-Kommission “Mamma”. Empfehlungen 2016 für die Behandlung des primären und des metastasierten Mammakarzinoms: www.ago-online.de
  2. Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer.N Engl J Med. 2012 Feb 9;366(6):520-9. 
  3. Blackwell KL, Burstein HJ, Storniolo AM, Rugo HS, Sledge G, Aktan G, Ellis C, Florance A, Vukelja S, Bischoff J, Baselga J, O'Shaughnessy J. Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study. J Clin Oncol. 2012 Jul 20;30(21):2585-92.
  4. Bossung V, Harbeck N. Angiogenesis inhibitors in the management of breast cancer. Curr Opin Obstet Gynecol. 2010 Feb;22(1):79-86.
  5. Cardoso F, Costa A, Norton L, Senkus E, Aapro M, André F, Barrios CH, Bergh J, Biganzoli L, Blackwell KL, Cardoso MJ, Cufer T, El Saghir N, Fallowfield L, Fenech D, Francis P, Gelmon K, Giordano SH, Gligorov J, Goldhirsch A, Harbeck N, Houssami N, Hudis C, Kaufman B, Krop I, Kyriakides S, Lin UN, Mayer M, Merjaver SD, Nordström EB, Pagani O, Partridge A, Penault-Llorca F, Piccart MJ, Rugo H, Sledge G, Thomssen C, Van't Veer L, Vorobiof D, Vrieling C, West N, Xu B, Winer E; European School of Oncology; European Society of Medical Oncology. ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2). Breast. 2014 Oct;23(5):489-502.
  6. Cristofanilli M, Turner NC, Bondarenko I, Ro J, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Zhang K, Theall KP, Jiang Y, Bartlett CH, Koehler M, Slamon D. Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol. 2016 Mar 2.
  7. Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members. -Tailoring therapies-improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015. Ann Oncol. 2015 Aug;26(8):1533-46.
  8. Colleoni M, Sun Z, Price KN, Karlsson P, Forbes JF, Thürlimann B, Gianni L, Castiglione M, Gelber RD, Coates AS, Goldhirsch A. Annual Hazard Rates of Recurrence for Breast Cancer During 24 Years of Follow-Up: Results From the International Breast Cancer Study Group Trials I to V. J Clin Oncol. 2016 Mar 20;34(9):927-35. 
  9. Couch FJ, Hart SN, Sharma P, Toland AE, Wang X, Miron P, Olson JE, Godwin AK, Pankratz VS, Olswold C, Slettedahl S, Hallberg E, Guidugli L, Davila JI, Beckmann MW, Janni W, Rack B, Ekici AB, Slamon DJ, Konstantopoulou I, Fostira F, Vratimos A, Fountzilas G, Pelttari LM, Tapper WJ, Durcan L, Cross SS, Pilarski R, Shapiro CL, Klemp J, Yao S, Garber J, Cox A, Brauch H, Ambrosone C, Nevanlinna H, Yannoukakos D, Slager SL, Vachon CM, Eccles DM, Fasching PA. Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer. J Clin Oncol. 2015 Feb 1;33(4):304-11.
  10. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Coleman R, Powles T, Paterson A, Gnant M, Anderson S, Diel I, Gralow J, von Minckwitz G, Moebus V, Bergh J, Pritchard KI, Bliss J, Cameron D, Evans V, Pan H, Peto R, Bradley R, Gray R. Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. Lancet. 2015 Oct 3;386(10001):1353-61.
  11. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Dowsett M, Forbes JF, Bradley R, Ingle J, Aihara T, Bliss J, Boccardo F, Coates A, Coombes RC, Cuzick J, Dubsky P, Gnant M, Kaufmann M, Kilburn L, Perrone F, Rea D, Thürlimann B, van de Velde C, Pan H, Peto R, Davies C, Gray R. Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. Lancet. 2015 Oct 3;386(10001):1341-52.
  12. Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO, Ettl J, Patel R, Pinter T, Schmidt M, Shparyk Y, Thummala AR, Voytko NL, Fowst C, Huang X, Kim ST, Randolph S, Slamon DJ. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol. 2015 Jan;16(1):25-35
  13. Francis PA, Regan MM, Fleming GF, Láng I, Ciruelos E, Bellet M, Bonnefoi HR, Climent MA, Da Prada GA, Burstein HJ, Martino S, Davidson NE, Geyer CE Jr, Walley BA, Coleman R, Kerbrat P, Buchholz S, Ingle JN, Winer EP, Rabaglio-Poretti M, Maibach R, Ruepp B, Giobbie-Hurder A, Price KN, Colleoni M, Viale G, Coates AS, Goldhirsch A, Gelber RD; SOFT Investigators; International Breast Cancer Study Group. Adjuvant ovarian suppression in premenopausal breast cancer. N Engl J Med. 2015 Jan 29;372(5):436-46. 
  14. Gluz O, Nitz UA, Christgen M, Kates RE, Shak S, Clemens M, Kraemer S, Aktas B, Kuemmel S, Reimer T, Kusche M, Heyl V, Lorenz-Salehi F, Just M, Hofmann D, Degenhardt T, Liedtke C, Svedman C, Wuerstlein R, Kreipe HH, Harbeck N. West German Study Group Phase III PlanB Trial: First Prospective Outcome Data for the 21-Gene Recurrence Score Assay and Concordance of Prognostic Markers by Central and Local Pathology Assessment. J Clin Oncol. 2016 Feb 29.
  15. Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Heck D, Menzel C, Jakesz R, Seifert M, Hubalek M, Pristauz G, Bauernhofer T, Eidtmann H, Eiermann W, Steger G, Kwasny W, Dubsky P, Hochreiner G, Forsthuber EP, Fesl C, Greil R; Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol. 2011 Jul;12(7):631-41.
  16. Gnant M, Pfeiler G, Dubsky PC, Hubalek M, Greil R, Jakesz R, Wette V, Balic M, Haslbauer F, Melbinger E, Bjelic-Radisic V, Artner-Matuschek S, Fitzal F, Marth C, Sevelda P, Mlineritsch B, Steger GG, Manfreda D, Exner R, Egle D, Bergh J, Kainberger F, Talbot S, Warner D, Fesl C, Singer CF; Austrian Breast and Colorectal Cancer Study Group. Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2015 Aug 1;386(9992):433-43.
  17. Harbeck N, Wuerstlein R. Optimal sequencing of anti-HER2 therapy throughout the continuum of HER2-positive breast cancer: evidence and clinical considerations. Drugs. 2013 Oct;73(15):1665-80.
  18. Knauer M, Filipits M, Dubsky P. Late recurrences in early breast cancer: for whom and how long is endocrine therapy beneficial? Breast Care (Basel). 2014 May;9(2):97-100. 
  19. Mackey JR, Pie?kowski T, Crown J, Sadeghi S, Martin M, Chan A, Saleh M, Sehdev S, Provencher L, Semiglazov V, Press MF, Sauter G, Lindsay M, Houé V, Buyse M, Drevot P, Hitier S, Bensfia S, Eiermann W; Translational Research In Oncology (TRIO)/ Breast Cancer International Research Group (BCIRG)-005 investigators. Long-term outcomes after adjuvant treatment of sequential versus combination docetaxel with doxorubicin and cyclophosphamide in node-positive breast cancer - BCIRG-005 randomized trial. Ann Oncol. 2016 Mar 2.
  20. Metzger Filho O, Giobbie-Hurder A, Mallon E, Gusterson B, Viale G, Winer EP, Thürlimann B, Gelber RD, Colleoni M, Ejlertsen B, Debled M, Price KN, Regan MM, Coates AS, Goldhirsch A. Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial. J Clin Oncol. 2015 Sep 1;33(25):2772-9. 
  21. Miles DW, Diéras V, Cortés J, Duenne AA, Yi J, O'Shaughnessy J. First-line bevacizumab in combination with chemotherapy for HER2-negative metastatic breast cancer: pooled and subgroup analyses of data from 2447 patients. Ann Oncol. 2013 Nov;24(11):2773-80.
  22. Moebus V, Jackisch C, Lueck HJ, du Bois A, Thomssen C, Kurbacher C, Kuhn W, Nitz U, Schneeweiss A, Huober J, Harbeck N, von Minckwitz G, Runnebaum IB, Hinke A, Kreienberg R, Konecny GE, Untch M. Intense dose-dense sequential chemotherapy with epirubicin, paclitaxel, and cyclophosphamide compared with conventionally scheduled chemotherapy in high-risk primary breast cancer: mature results of an AGO phase III study. J Clin Oncol. 2010 Jun 10;28(17):2874-80. 
  23. Pagani O, Regan MM, Francis PA; TEXT and SOFT Investigators; International Breast Cancer Study Group. Exemestane with ovarian suppression in premenopausal breast cancer. N Engl J Med. 2014 Oct 2;371(14):1358-9.
  24. Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, Børresen-Dale AL, Brown PO, Botstein D. Molecular portraits of human breast tumours. Nature. 2000 Aug 17;406(6797):747-52.
  25. Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, Geyer CE Jr, Dees EC, Perez EA, Olson JA Jr, Zujewski J, Lively T, Badve SS, Saphner TJ, Wagner LI, Whelan TJ, Ellis MJ, Paik S, Wood WC, Ravdin P, Keane MM, Gomez Moreno HL, Reddy PS, Goggins TF, Mayer IA, Brufsky AM, Toppmeyer DL, Kaklamani VG, Atkins JN, Berenberg JL, Sledge GW. Prospective Validation of a 21-Gene Expression Assay in Breast Cancer. N Engl J Med. 2015 Nov 19;373(21):2005-14. 
  26. Sparano JA, Zhao F, Martino S, Ligibel JA, Perez EA, Saphner T, Wolff AC, Sledge GW Jr, Wood WC, Davidson NE. Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer. J Clin Oncol. 2015 Jul 20;33(21):2353-60. 
  27. Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, Lichinitser M, Fujiwara Y, Yardley DA, Viniegra M, Fan M, Jiang Q, Dansey R, Jun S, Braun A. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol. 2010 Dec 10;28(35):5132-9. 
  28. Swain SM, Baselga J, Kim SB, Ro J, Semiglazov V, Campone M, Ciruelos E, Ferrero JM, Schneeweiss A, Heeson S, Clark E, Ross G, Benyunes MC, Cortés J; CLEOPATRA Study Group. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med. 2015 Feb 19;372(8):724-34. 
  29. Tolaney SM, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Shapira I, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Guo H, Hudis CA, Krop IE, Burstein HJ, Winer EP. Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer. N Engl J Med. 2015 Jan 8;372(2):134-41. 
  30. Van Poznak CH, Temin S, Yee GC, Janjan NA, Barlow WE, Biermann JS, Bosserman LD, Geoghegan C, Hillner BE, Theriault RL, Zuckerman DS, Von Roenn JH; American Society of Clinical Oncology. American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J Clin Oncol. 2011 Mar 20;29(9):1221-7. 
  31. Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K; EMILIA Study Group. Trastuzumab emtansine for HER2-positive advanced breast cancer.N Engl J Med. 2012 Nov 8;367(19):1783-91.
  32. von Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA, Gerber B, Eiermann W, Hilfrich J, Huober J, Jackisch C, Kaufmann M, Konecny GE, Denkert C, Nekljudova V, Mehta K, Loibl S. Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes. J Clin Oncol. 2012 30(15):1796-804. 
  33. von Minckwitz G, Schneeweiss A, Loibl S, Salat C, Denkert C, Rezai M, Blohmer JU, Jackisch C, Paepke S, Gerber B, Zahm DM, Kümmel S, Eidtmann H, Klare P, Huober J, Costa S, Tesch H, Hanusch C, Hilfrich J, Khandan F, Fasching PA, Sinn BV, Engels K, Mehta K, Nekljudova V, Untch M. Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial. Lancet Oncol. 2014 Jun;15(7):747-56
  34. Yin W, Jiang Y, Shen Z, Shao Z, Lu J. Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: a meta-analysis of published randomized controlled trials.PLoS One. 2011;6(6):e21030. 

Hot Topics in der adjuvanten Radiotherapie des brusterhaltend operierten Mammakarzinoms

Petra Feyer (S. 18)

 

  1. AGO (Arbeitsgemeinschaft Gynäkologische Onkologie „Diagnosis and treatment of patients with primary or metastasic breast cancer – adjuvant radiotherapy“ www.aoorg 2016 www.ago-online.de
  2. Advani, P. P., K. V. Ballman, T. J. Dockter, G. Colon-Otero, and E. A. Perez. 2016. “Long-Term Cardiac Safety Analysis of NCCTG N9831 (Alliance) Adjuvant Trastuzumab Trial..” Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34(6):581–87.
  3. Bane, A. L. et al. 2014. “Tumor Factors Predictive of Response to Hypofractionated Radiotherapy in a Randomized Trial Following Breast Conserving Therapy..” Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 25(5):992–98.
  4. Boekel, N. B. et al. 2014. “Cardiovascular Morbidity and Mortality After Treatment for Ductal Carcinoma in Situ of the Breast.” JNCI Journal of the National Cancer Institute 106(8):dju156–56.
  5. Caussa, L. et al. 2011. “The Acute Skin and Heart Toxicity of a Concurrent Association of Trastuzumab and Locoregional Breast Radiotherapy Including Internal Mammary Chain: a Single-Institution Study.” European Journal of Cancer 47(1):65–73.
  6. Ciervide R, Dhage S, Guth A, et al: Five year outcome of 145 patients with ductalcarcinoma in situ (DCIS) after accelerated breast radiotherapy. Int J Radiat Oncol Biol Phys 2012; 83:e 159-e164.
  7. Dellas K, Vonthein R, Zimmer J, et al.: ARO study Group: Hypofractionation with simultaneous integrated boost for early breast cancer: results of the German ,ulticenter phase II trial (ARO-2010-01). Strahlenther Onkol 2014; 190: 646-653.
  8. Donker, M. et al. 2014. “Radiotherapy or Surgery of the Axilla After a Positive Sentinel Node in Breast Cancer (EORTC 10981-22023 AMAROS): a Randomised, Multicentre, Open-Label, Phase 3 Non-Inferiority Trial..” The Lancet Oncology 15(12):1303–10.
  9. Fisher CM, Rabinovitch R.: Frontiers in radiotherapy for early-stage invasive breast cancer. J Clin Oncol 2014; 32: 2894-2901.
  10. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). 2010. “Overview of the Randomized Trials of Radiotherapy in Ductal Carcinoma in Situ of the Breast.” JNCI Monographs 2010(41):162–77.
  11. Elshof, L. E. et al. 2015. “Feasibility of a Prospective, Randomised, Open-Label, International Multicentre, Phase III, Non-Inferiority Trial to Assess the Safety of Active Surveillance for Low Risk Ductal Carcinoma in Situ - the LORD Study..” European journal of cancer (Oxford, England : 1990) 51(12):1497–1510.
  12. Fitzal, F. et al. 2015. “The Genomic Expression Test EndoPredict Is a Prognostic Tool for Identifying Risk of Local Recurrence in Postmenopausal Endocrine Receptor-Positive, Her2neu-Negative Breast Cancer Patients Randomised Within the Prospective ABCSG 8 Trial.” British Journal of Cancer 112(8):1405–10.
  13. Francis, A. et al. 2015. “Addressing Overtreatment of Screen Detected DCIS; the LORIS Trial.” European Journal of Cancer 51(16):2296–2303.
  14. Giuliano, A. E. et al. 2010. “Locoregional Recurrence After Sentinel Lymph Node Dissection with or Without Axillary Dissection in Patients with Sentinel Lymph Node Metastases: the American College of Surgeons Oncology Group Z0011 Randomized Trial..” Annals of Surgery 252(3):426–32–discussion432–3.
  15. Giuliano, A. E. et al. 2011. “Axillary Dissection vs No Axillary Dissection in Women with Invasive Breast Cancer and Sentinel Node Metastasis: a Randomized Clinical Trial..” JAMA 305(6):569–75.
  16. Halyard MY, Pisansky TM, Druck AC, et al.: Radiotherapy and adjuvant trastuzumab in operable breast cancer: tolerably and adverse event data from the NCCTG Phase III Trial N9831. J Clin Oncol 2009; 27: 2638-2644.
  17. Hathout L, Hijal T, Theberge V, et al: Hypofractionated radiation therapy for breast ductal carcinoma in situ. Int J Radiat Oncol biol Phys 2013; 87: 1058-106.
  18. Haviland JS, Owen JR, Dower JA, et al.: START Trialist`Group: The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow up results of two randomised controlled trials. Lancet Oncol 2013; 14: 1086-1094.
  19. Hennequin C, Dubray B: Alpha/beta ratio revisited in the era of hypofractionation. Cancer Radiother 2013; 17: 344-348.
  20. Hennequin C, Bossard N, Servagi-Vernat S, et al 2013. Ten-Year Survival Results of a Randomized Trial of Irradiation of Internal Mammary Nodes After Mastectomy. International journal of radiation oncology biology physics. Aug1, 86 (5):860-6, doi: 10.1016/j.ijrobp.2013.03.021
  21. Jagsi, R. et al. 2014. “Radiation Field Design in the ACOSOG Z0011 (Alliance) Trial..” Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32(32):3600–3606.
  22. Jeyakumar A, Younis T: Tratuzumab for HER 2-positive metastatic breast cancer: clinical and economic considerations. Clin Med Insigts Oncol 2012; 6: 179-187.
  23. Krug, D. and R. Souchon. 2015. “Radiotherapy of Ductal Carcinoma in Situ.” Breast Care 10(4):259–64.
  24. Lynge, E. et al. 2014. “Variation in Detection of Ductal Carcinoma in Situ During Screening Mammography: a Survey Within the International Cancer Screening Network.” European Journal of Cancer 50(1):185–92.
  25. McCormick, B. et al. 2015. “RTOG 9804: a Prospective Randomized Trial for Good-Risk Ductal Carcinoma in Situ Comparing Radiotherapy with Observation.” Journal of Clinical Oncology 33(7):709–15.
  26. Merrill, A. L., L. Esserman, and M. Morrow. 2016. “CLINICAL DECISIONS. Ductal Carcinoma in Situ..” The New England journal of medicine 374(4):390–92.
  27. Narod, S. A., J. Iqbal, V. Giannakeas, V. Sopik, and P. Sun. 2015. “Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma in Situ.” JAMA Oncology 1(7):888–89.
  28. Nielsson C, Valachis A.: The role of boost and hypofractionation as adjuvant radiotherapy in patinets with DCIS: a meta-analysis of observational studies. Radiother Oncol 2015; Jan; 114(1): 50-55. 
  29. Owen, J. R. et al. 2006. “Effect of Radiotherapy Fraction Size on Tumour Control in Patients with Early-Stage Breast Cancer After Local Tumour Excision: Long-Term Results of a Randomised Trial..” Lancet Oncology 7(6):467–71.
  30. Poortmans, P. M. et al. 2015. “Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer.” The New England journal of medicine 373(4):317–27.
  31. Reimer, T., S. Hartmann, A. Stachs, and B. Gerber. 2014. “Local Treatment of the Axilla in Early Breast Cancer: Concepts From the National Surgical Adjuvant Breast and Bowel Project B-04 to the Planned Intergroup Sentinel Mamma Trial.” Breast Care 9(2):1–1.
  32. Riemer AB, Zieleinski CC: Use of trastuzumab in the therapy of breast cancer. Ther Umsch 2008; 65: 217-222.
  33. Sautter-Bihl ML, Sedlmayer F, Budach W, et al. DEGRO practical guidelines: radiotherapy of breast cancer III-radiotherapy of the lymphatic pathways. Strahlenther. Onkol. 204; 190:342-51
  34. Sautter-Bihl ML, Sedlmayer F, Budach W, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Piroth MD, Souchon R, Wenz F, Sauer R; Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO). Strahlenther Onkol. 2014 Oct; 190 (10):861-3, doi: 10. 1007/s00066-014-0755-5. How nescience may obscure evidence. Strahlenther Onkol. 2014 Oct; 190(10):861-3. doi: 10 1007/s00066-014-0755-5.
  35. Sedlmayer, F. et al. 2013. “DEGRO Practical Guidelines: Radiotherapy ofBreast Cancer I: Radiotherapy Following Breast Conserving Therapy for Invasive Breast Cancer..” Strahlentherapie und Onkologie 189(10):825–33.
  36. Solin, L. J. et al. 2013. “A Multigene Expression Assay to Predict Local Recurrence Risk for Ductal Carcinoma in Situ of the Breast.” JNCI Journal of the National Cancer Institute 105(10):701–10.
  37. Subhedar, P., C. Olcese, S. Patil, M. Morrow, and K. J. Van Zee. 2015. “Decreasing Recurrence Rates for Ductal Carcinoma in Situ: Analysis of 2996 Women Treated with Breast-Conserving Surgery Over 30 Years..” Annals of Surgical Oncology 22(10):3273–81.
  38. Suh, W. W., B. E. Hillner, L. J. Pierce, and J. A. Hayman. 2005. “Cost-Effectiveness of Radiation Therapy Following Conservative Surgery for Ductal Carcinoma in Situ of the Breast.” International Journal of Radiation Oncology*Biology*Physics 61(4):1054–61.Thames HD, Bentzen SM, Turesson I. et al. : time-dose factors in radiotherapy: a review of the human data. Radiother Oncol 1990; 19:219-235.
  39. Thames HD, Withers HR, Peters LJ, Fletscher GH: changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int. J Radiat Oncol Biol Phys 1982; 8:219-222.
  40. Trans Tasman Radiation Oncology Group: BIG 3-07: A randomised phase III study of radiation doses and fractionation schedules for ductal carcinoma in situ (DCIS) of the breast. www.rttrialsqa.org.uk/rttqa/
  41. Thorsen, L. B. J. et al. 2016. “DBCG-IMN: a Population-Based Cohort Study on the Effect of Internal Mammary Node Irradiation in Early Node-Positive Breast Cancer..” Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34(4):314–20.
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  43. Van Zee, K. J. et al. 2003. “A Nomogram for Predicting the Likelihood of Additional Nodal Metastases in Breast Cancer Patients with a Positive Sentinel Node Biopsy.” Annals of Surgical Oncology 10(10):1140–51.
  44. Virnig, B. A., T. M. Tuttle, T. Shamliyan, and R. L. Kane. 2010. “Ductal Carcinoma in Situ of the Breast: a Systematic Review of Incidence, Treatment, and Outcomes.” JNCI Journal of the National Cancer Institute 102(3):170–78.Wai Es, Lesperance ML, Alexander CS, et al: Effect of radiotherapy boost and hypofractionation on outcomes in ductal carcinoma in situ. Cancer 2011; 117: 54-62.
  45. Whelan TJ, Pignol JP, Levine MN, et al. : Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 2010; 362: 513-520.
  46. Whelan, T. J. et al. 2015. “Regional Nodal Irradiation in Early-Stage Breast Cancer.” The N Engl J Med 373(4):307–16.
  47. Williamson D, Dinniwell R, Fung S, et al.: Local control with conventional and hypofractionated adjuvant radiotherapy after breast-conserving surgery for ductal carcinoma in-situ. Radiother Oncol 95: 317-320, 2010.
  48. Yarnold, J. et al. 2005. “Fractionation Sensitivity and Dose Response of Late Adverse Effects in the Breast After Radiotherapy for Early Breast Cancer: Long-Term Results of a Randomised Trial.” Radiotherapy and Oncology 75(1):9–17.
  49. Yarnold, J., S. M. Bentzen, C. Coles, and J. Haviland. 2011. “Hypofractionated Whole-Breast Radiotherapy for Women with Early Breast Cancer: Myths and Realities..” International journal of radiation oncology, biology, physics 79(1):1–9.

Die plastische Rekonstruktion der Brust

Manuel Hrabowski (S. 25)

 

  1. Gerber B, Marx M, Untch M, Faridi A: Breast reconstruction following cancer treatment. Dtsch Arztebl Int 2015; 112: 593–600.
  2. Atisha DM, Rushing CN, Samsa GP, et al.: A national snapshot of satisfaction with breast cancer procedures. Ann Surg Oncol 2015; 22: 361–9.
  3. Alderman AK, Kuhn LE, Lowery JC, Wilkins EG: Does patient satisfaction with breast reconstruction change over time? Two-year results of the Michigan Breast Reconstruction Outcomes Study. J Am Coll Surg. 2007 Jan; 204(1):7-12.
  4. Gabriel SE, Woods JE, O’fallon WM et al (1997) Complications leading to surgery after breast im-plantation. N Engl J Med 336:677–682
  5. Behranwala KA, Dua RS, Ross GM et al (2006) The influence of radiotherapy on capsule formation and aesthetic outcome after immediate breast re¬construction using biodimensional anatomical ex-pander implants. J Plast Reconstr Aesthet Surg 59:1043–1051
  6. Cemal Y, Albornoz CR, Disa JJ, et al.: A paradigm shift in U.S. breast reconstruction: Part 2. The influence of changing mastectomy patterns on reconstructive rate and method. Plast Reconstr Surg 2013; 131: 320e–6e.
  7. Platt J, Baxter N, Zhong T: Breast reconstruction after mastectomy for breast cancer. CMAJ. 2011 Dec 13;183(18):2109-16
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Vakzinierungsstrategien: Mechanismen, Erfolge und Ausblicke

Jens Bedke (S. 30)

 

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Patienten und ihre Angehörigen schlechte Nachrichten richtig überbringen

Anna Stickl und Ute Goerling (S. 33)

 

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Update: Diagnostik und Therapieoptionen des Prostatakarzinoms

Markus Graefen (S. 50)

 

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Pharmaforum - Optimaler Therapieerfolg mit Leitlinien-gerechtem Einsatz von Bevacizumab

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Pharmaforum - Hohe Überlebensrate mit Herceptin auch nach zehn Jahren bestätigt

(S. 60)

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Pharmaforum - Azacitidin verlängert das Gesamtüberleben von älteren AML-Patienten mit mehr als 30% Blasten

(S. 63)

 

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