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SCHWERPUNKT:
HERZINSUFFIZIENZ: INTERVENTIONELLE BZW DEVICE-THERAPIE

Baroreflexaktivierungstherapie und kardiale Kontraktilitätsmodulation – BAT und CCM (S. 23–27)
David Duncker, Johann Bauersachs, Christian Veltmann

  1. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal. The Oxford University Press; 2016 May 20; ehw128–85
  2. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). European Heart Journal 2015 Nov 1; 36(41): 2793–867
  3. Sipahi I, Chou JC, Hyden M, Rowland DY, Simon DI, Fang JC. Effect of QRS morphology on clinical event reduction with cardiac resynchronization therapy: meta-analysis of randomized controlled trials. Am Heart J 2012 Feb; 163(2): 260–3
  4. Cleland JG, Abraham WT, Linde C, Gold MR, Young JB, Claude Daubert J, et al. An individual patient meta-analysis of five randomized trials assessing the effects of cardiac resynchronization therapy on morbidity and mortality in patients with symptomatic heart failure. European Heart Journal 2013 Dec; 34(46): 3547–56
  5. Shah RM, Patel D, Molnar J, Ellenbogen KA, Koneru JN. Cardiac-resynchronization therapy in patients with systolic heart failure and QRS interval ≤ 130 ms: insights from a meta-analysis. Europace 2015 Feb; 17(2): 267–73
  6. Ruschitzka F, Abraham WT, Singh JP, Bax JJ, Borer JS, Brugada J, et al. Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med 2013 Oct 10; 369(15): 1395–405
  7. Shenkman HJ, Pampati V, Khandelwal AK, McKinnon J, Nori D, Kaatz S, et al. Congestive heart failure and QRS duration: establishing prognosis study. Chest 2002 Aug; 122(2): 528–34
  8. Randolph TC, Broderick S, Shaw LK, Chiswell K, Mentz RJ, Kutyifa V, et al. Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction. J Am Heart Assoc 2017 Mar 20; 6(3)
  9. Chatterjee NA, Singh JP. Novel Interventional Therapies to Modulate the Autonomic Tone in Heart Failure. JACC Heart Fail 2015 Oct; 3(10): 786–802
  10. van Bilsen M, Patel HC, Bauersachs J, Böhm M, Borggrefe M, Brutsaert D, et al. The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2017 Nov; 19(11): 1361–78
  11. Gold MR, Van Veldhuisen DJ, Hauptman PJ, Borggrefe M, Kubo SH, Lieberman RA, et al. Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial. Journal of the American College of Cardiology 2016 Jul 12; 68(2): 149–58
  12. Zipes DP, Neuzil P, Theres H, Caraway D, Mann DL, Mannheimer C, et al. Determining the Feasibility of Spinal Cord Neuromodulation for the Treatment of Chronic Systolic Heart Failure: The DEFEAT-HF Study. JACC Heart Fail 2016 Feb; 4(2): 129–36
  13. Bisognano JD, Bakris G, Nadim MK, Sanchez L, Kroon AA, Schafer J, et al. Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal trial. Journal of the American College of Cardiology 2011 Aug 9; 58(7): 765–73
  14. Florea VG, Cohn JN. The autonomic nervous system and heart failure. Circ Res. American Heart Association, Inc; 2014 May 23; 114(11): 1815–26
  15. Zucker IH, Hackley JF, Cornish KG, Hiser BA, Anderson NR, Kieval R, et al. Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure. Hypertension 2007 Nov; 50(5): 904–10
  16. Sabbah HN, Gupta RC, Imai M, Irwin ED, Rastogi S, Rossing MA, et al. Chronic electrical stimulation of the carotid sinus baroreflex improves left ventricular function and promotes reversal of ventricular remodeling in dogs with advanced heart failure. Circ Heart Fail 2011 Jan; 4(1): 65–70
  17. Gronda E, Seravalle G, Brambilla G, Costantino G, Casini A, Alsheraei A, et al. Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof-of-concept study. Eur J Heart Fail 2014 Sep; 16(9): 977–83
  18. Abraham WT, Zile MR, Weaver FA, Butter C, Ducharme A, Halbach M, et al. Baroreflex Activation Therapy for the Treatment of Heart Failure With a Reduced Ejection Fraction. JACC Heart Fail 2015 Jun; 3(6): 487–96
  19. Zile MR, Abraham WT, Weaver FA, Butter C, Ducharme A, Halbach M, et al. Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction: safety and efficacy in patients with and without cardiac resynchronization therapy. Eur J Heart Fail 2015 Oct; 17(10): 1066–74
  20. Röger S, Said S, Kloppe A, Lawo T, Emig U, Rousso B, et al. Cardiac contractility modulation in heart failure patients: Randomized comparison of signal delivery through one vs. two ventricular leads. J Cardiol 2017 Jan; 69(1): 326–32
  21. Kuschyk J, Stach K, Tülümen E, Rudic B, Liebe V, Schimpf R, et al. Subcutaneous implantable cardioverter-defibrillator: First single-center experience with other cardiac implantable electronic devices. Heart Rhythm 2015 Nov; 12(11): 2230–8
  22. Kloppe A, Mijic D, Schiedat F, Bogossian H, Mügge A, Rousso B, et al. A randomized comparison of 5 versus 12 hours per day of cardiac contractility modulation treatment for heart failure patients: A preliminary report. Cardiol J 2016; 23(1): 114–9
  23. Butter C, Wellnhofer E, Schlegl M, Winbeck G, Fleck E, Sabbah HN. Enhanced inotropic state of the failing left ventricle by cardiac contractility modulation electrical signals is not associated with increased myocardial oxygen consumption. Journal of Cardiac Failure 2007 Mar; 13(2): 137–42
  24. Burkhoff D, Shemer I, Felzen B, Shimizu J, Mika Y, Dickstein M, et al. Electric currents applied during the refractory period can modulate cardiac contractility in vitro and in vivo. Heart Fail Rev 2001 Jan; 6(1): 27–34
  25. Morita H, Suzuki G, Haddad W, Mika Y, Tanhehco EJ, Sharov VG, et al. Cardiac contractility modulation with nonexcitatory electric signals improves left ventricular function in dogs with chronic heart failure. Journal of Cardiac Failure 2003 Feb; 9(1): 69–75
  26. Morita H, Suzuki G, Haddad W, Mika Y, Tanhehco EJ, Goldstein S, et al. Long-term effects of non-excitatory cardiac contractility modulation electric signals on the progression of heart failure in dogs. Eur J Heart Fail 2004 Mar 1; 6(2): 145–50
  27. Lyon AR, Samara MA, Feldman DS. Cardiac contractility modulation therapy in advanced systolic heart failure. Nat Rev Cardiol. Nature Publishing Group; 2013 Oct; 10(10): 584–98
  28. Butter C, Rastogi S, Minden H-H, Meyhöfer J, Burkhoff D, Sabbah HN. Cardiac contractility modulation electrical signals improve myocardial gene expression in patients with heart failure. Journal of the American College of Cardiology 2008 May 6; 51(18): 1784–9
  29. Pappone C, Rosanio S, Burkhoff D, Mika Y, Vicedomini G, Augello G, et al. Cardiac contractility modulation by electric currents applied during the refractory period in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2002 Dec 15; 90(12): 1307–13
  30. Stix G, Borggrefe M, Wolpert C, Hindricks G, Kottkamp H, Böcker D, et al. Chronic electrical stimulation during the absolute refractory period of the myocardium improves severe heart failure. European Heart Journal 2004 Apr; 25(8): 650–5
  31. Borggrefe MM, Lawo T, Butter C, Schmidinger H, Lunati M, Pieske B, et al. Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure. European Heart Journal 2008 Apr; 29(8): 1019–28
  32. Kadish A, Nademanee K, Volosin K, Krueger S, Neelagaru S, Raval N, et al. A randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure. Am Heart J 2011 Feb; 161(2): 329–337.e1–2
  33. Abraham WT, Nademanee K, Volosin K, Krueger S, Neelagaru S, Raval N, et al. Subgroup analysis of a randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure. Journal of Cardiac Failure 2011 Sep; 17(9): 710–7
  34. Schau T, Seifert M, Meyhöfer J, Neuss M, Butter C. Long-term outcome of cardiac contractility modulation in patients with severe congestive heart failure. Europace 2011 Oct; 13(10): 1436–44
  35. Kuschyk J, Roeger S, Schneider R, Streitner F, Stach K, Rudic B, et al. Efficacy and survival in patients with cardiac contractility modulation: long-term single center experience in 81 patients. Int J Cardiol 2015 Mar 15; 183: 76–81
  36. Kloppe A, Lawo T, Mijic D, Schiedat F, Muegge A, Lemke B. Long-term survival with Cardiac Contractility Modulation in patients with NYHA II or III symptoms and normal QRS duration. Int J Cardiol 2016 Apr 15; 209: 291–5
  37. Liu M, Fang F, Luo XX, Shlomo B-H, Burkhoff D, Chan JYS, et al. Improvement of long-term survival by cardiac contractility modulation in heart failure patients: A case-control study. Int J Cardiol 2016 Mar 1; 206: 122–6
  38. Grigioni F, Carinci V, Boriani G, Bracchetti G, Potena L, Magnani G, et al. Accelerated QRS widening as an independent predictor of cardiac death or of the need for heart transplantation in patients with congestive heart failure. J Heart Lung Transplant 2002 Aug; 21(8): 899–902
  39. Röger S, Michels J, Heggemann F, Stach K, Rousso B, Borggrefe M, et al. Long term impact of cardiac contractility modulation on QRS duration. J Electrocardiol 2014 Nov; 47(6): 936–40
  40. Nagele H, Behrens S, Eisermann C. Cardiac contractility modulation in non-responders to cardiac resynchronization therapy. Europace 2008 Dec; 10(12): 1375–80

 

Die Angehörigen von Herzinfarktpatienten – ein altes, aber dennoch aktuelles Thema (S. 28–33)
Stefan Lueger, Tanja Lueger, Peter Deeg

  1. Halhuber C. Die Einbeziehung des Partners in die umfassende Behandlung des Infarktkranken. In: Langosch W, Hrsg. Psychische Bewältigung der chronischen Herzerkrankung. Berlin: Springer; 1985. S.290–298
  2. Randall G, Molloy GJ, Steptoe A. The impact of an acute cardiac event on the partners of patients: A systematic review. Health Psychol Rev 2009; 3: 1–84
  3. Eriksson M, Asplund K, Svedlund M. Patients’ and their partners’ experiences of returning home after hospital discharge following acute myocardial infarction. Eur J Cardiovasc Nurs 2009; 8: 267–273
  4. Nadarajah SR, Buchholz SW, Wiegand DL, Berger A. The lived experience of individuals in cardiac rehabilitation who have a positive outlook on their cardiac recovery: A phenomenological inquiry. Eur J Cardiovasc Nurs 2016; 16: 230–239
  5. Doherty WJ, Schrott HG, Metcalf L, Iasiello-Vailas L. Effect of spouse support and health beliefs on medication adherence. J Fam Pract 1983; 17: 837–841
  6. Mosca L, Mochari-Greenberger H, Aggarwal B, Liao M, Suero-Tejeda N, Comellas M, Rehm L, Umann TM, Mehran R. Patterns of caregiving among patients hospitalized with cardiovascular disease. J Cardiovasc Nurs 2011; 26: 305–311
  7. Son H, Friedmann E, Thomas SA. Changes in depressive symptoms in spouses of post myocardial infarction patients. Asian Nurs Re. 2012; 6: 158–165
  8. Joekes K, Maes S, Boersma SN, Van Elderen T. Goal disturbance, coping, and psychological distress in partners of myocardial infarction patients: Taking account of the dyad. Anxiety, Stress Coping 2005; 18: 255–267
  9. Löwe B, Wahl I, Rose M, Spitzer C, Glaesmer H, Wingenfeld K, Schneider A, Brähler E. A 4-item measure of depression and anxiety: Validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population. J Affect Disord 2010; 122: 86–95
  10. O’Farrell P, Murray J, Hotz SB. Psychologic distress among spouses of patients undergoing cardiac rehabilitation. Heart Lung 2000; 29: 97–104
  11. Bennett P, Connell H. Dyadic processes in response to myocardial infarction. Psychol Health Med 1999; 4: 45–55
  12. Moser DK, Dracup K. Role of spousal anxiety and depression in patients’ psychosocial recovery after a cardiac event. Psychosom Med 2004; 66: 527–532
  13. Nilsson UG, Ivarsson B, Alm‐Roijer C, Svedberg P. The desire for involvement in healthcare, anxiety and coping in patients and their partners after a myocardial infarction. Eur J Cardiovasc Nurs 2013; 12: 461–467
  14. . Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jönsson B, Olesen J, Allgulander C, Alonso J, Faravelli C, Fratiglioni L, Jennum P, Lieb R, Maercker A, van Os J, Preisig M, Salvador-Carulla L, Simon R, Steinhausen HC. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011; 21: 655–679
  15. Hagedoorn M, Sanderman R, Bolks HN, Tuinstra J, Coyne JC. Distress in couples coping with cancer: A meta-analysis and critical review of role and gender effects. Psychol Bull 2008; 134: 1–30
  16. Leigh, ES, Wikman A, Molloy GJ, Randall G, Steptoe A. The psychosocial predictors of long-term distress in partners of patients with acute coronary syndrome. Psychol Health 2014; 29: 737–752
  17. Vilchinsky N. Unrecognized, undiagnosed, and untreated: Cardiac-disease-induced PTSD among patients’ partners. Front Psychol 2017; 8: 1265
  18. Fait K, Vilchinsky N, Dekel R, Levi N, Hod H, Matetzky S Cardiac disease-induced post-traumatic stress symptoms (CDI-PTSS) among patients' partners. Stress Health 2017; 33: 169–176
  19. Kettunen S, Solovieva S, Santavirta N. Myocardial infarction, spouses’ reaction and their need for support. J Adv Nurs 1999; 30: 479–488
  20. Blair J, Volpe M, Aggarwal B. Challenges, needs, and experiences of recently hospitalized cardiac patients and their informal caregivers. J cardiovasc nurs 2014; 29: 29–37
  21. Hatfield E, Cacioppo JT, Rapson RL. Emotional contagion. New York: Cambridge University Press; 1994
  22. Bookwala J, Schulz R. Spousal similarity in subjective well-being: The cardiovascular health study. Psychol Aging 1996; 11: 582–590
  23. Coyne JC, Smith DA. Couples coping with a myocardial infarction: A contextual perspective on wives’ distress. J Pers Soc Psychol 1991; 61: 404–412
  24. Taylor CB, Bandura A, Ewart CK, Miller NH, DeBusk R F. Exercise testing to enhance wives. Confidence in their husbands capabilities soon after clinically uncomplicated acute myocardial infarction. A J Cardiol 1985; 55: 635–638
  25. Joekes K, Maes S, Warrens M. Predicting quality of life and self management from dyadic support and overprotection after myocardial infarction. Br J Health Psychol 2007; 12: 473–489
  26. Santavirta N, Kettunen S, Solovieva S. Coping in spouses of patients with acute myocardial infarction in the early phase of recovery. J Cardiovasc Nurs 2001; 16: 34–46
  27. Mancia G, Fagard R et al.  ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34:2159–219
  28. Moser DK, Dracup KA, Marsden C. Needs of recovering cardiac patients and their spouses: Compared views. Int J Nurs Stud 1993; 30: 105–114
  29. Turton J. Importance of information following myocardial infarction: a study of the self-perceived information needs of patients and their spouse/partner compared with the perceptions of nursing staff. J Adv Nurs 1998; 27: 770–778
  30. Martire LM, Schulz R, Helgeson VS, Small BJ, Saghafi EM. Review and meta-analysis of couple-oriented interventions for chronic illness. Ann Behav Med 2010; 40: 325–342
  31. Whalley B, Rees K, Davies P, Bennett P, Ebrahim S, Liu Z, West R, Moxham T, Thompson DR, Taylor RS. Psychological interventions for coronary heart disease. Cochrane Database Syst Rev 2011; 8: CD002902
  32. Richards SH, Anderson L, Jenkinson CE, Whalley B, Rees K, Davies P, Bennett P, Liu Z, West R, Thompson DR, Taylor RS. Psychological interventions for coronary heart disease. Cochrane Database Syst Rev 2017; 4: CD002902
  33. Collins R, Reith C, Emberson J, Armitage J, Baigent C, Blackwell L, Blumenthal R, Danesh J, Smith GD, DeMets D, Evans S, Law M, MacMahon S, Martin S, Neal B, Poulter N, Preiss D, Ridker P, Roberts I, Rodgers A, Sandercock P, Schulz K, Sever P, Simes J, Smeeth L, Wald N, Yusuf S, Peto R. Interpretation of the evidence for the efficacy and safety of statin therapy.  Lancet 2016; 388:2532–2561
  34. Priebe S, Sinning U. Effects of a brief couples therapy intervention in coronary rehabilitation. A controlled study. Psychother Psychosom Med Psychol 2001; 51: 276–280http://14651858.CD007514.pub
  35. Priebe S, Sinning U. Paartherapeutisches Vorgehen in der Rehabilitation von Koronarpatienten. Verhaltensmodifikation und Verhaltensmedizin. 1989; 10: 239–252
  36. Schulz von Thun F. Miteinander reden. 1. Störungen und Klärungen. Reinbek: Rowohlt; 1999

 

CME:
Interventionelle Therapie der funktionellen Mitralinsuffizienz (S. 35–39)
Julian D. Widder, Johann Bauersachs

  1. Trichon BH, Felker GM, Shaw LK, Cabell CH, O'Connor CM. Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure. Am J Cardiol 2003; 91(5): 538–43
  2. Kaneko H, Suzuki S, Uejima T, Kano H, Matsuno S, Takai H, et al. Functional mitral regurgitation and left ventricular systolic dysfunction in the recent era of cardiovascular clinical practice, an observational cohort study. Hypertens Res 2014; 37(12): 1082–7
  3. Ruhla, S., et al., Levothyroxine medication is associated with adiposity independent of TSH. Exp Clin Endocrinol Diabetes, 2012. 120(6): p. 351–4.
  4. Grigioni F, Enriquez-Sarano M, Zehr KJ, Bailey KR, Tajik AJ. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation 2001; 103(13): 1759–64
  5. Rossi A, Dini FL, Faggiano P, Agricola E, Cicoira M, Frattini S, et al. Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. Heart 2011; 97(20): 1675–80
  6. Mirabel M, Iung B, Baron G, Messika-Zeitoun D, Detaint D, Vanoverschelde JL, et al. What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery? Eur Heart J 2007; 28(11): 1358–65
  7. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet 2006; 368(9540): 1005–11
  8. Baldus S, Kuck KH, Rudolph V, Nef H, Eggebrecht H, Boekstegers P, et al. Interventionelle Therapie von AV-Klappenerkrankungen – Fokus Mitralklappeninsuffizienz. Kardiologe 2018; 12(2): 128–44
  9. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016; 37(27): 2129–200
  10. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, et al. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2017; 38(36): 2739–91
  11. Alfieri O, Denti P. Alfieri stitch and its impact on mitral clip. Eur J Cardiothorac Surg 2011; 39(6): 807–8
  12. Feldman T, Foster E, Glower DD, Kar S, Rinaldi MJ, Fail PS, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 2011; 364(15): 1395–406
  13. Feldman T, Kar S, Elmariah S, Smart SC, Trento A, Siegel RJ, et al. Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation: 5-Year Results of EVEREST II. J Am Coll Cardiol 2015; 66(25): 2844–54
  14. Maisano F, Franzen O, Baldus S, Schafer U, Hausleiter J, Butter C, et al. Percutaneous mitral valve interventions in the real world: early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe. J Am Coll Cardiol 2013; 62(12): 1052–61
  15. Puls M, Lubos E, Boekstegers P, von Bardeleben RS, Ouarrak T, Butter C, et al. One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry. Eur Heart J 2016; 37(8): 703–12
  16. Velazquez EJ, Samad Z, Al-Khalidi HR, Sangli C, Grayburn PA, Massaro JM, et al. The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: A propensity-matched comparison. Am Heart J 2015; 170(5): 1050–9 e3
  17. Praz F, Spargias K, Chrissoheris M, Bullesfeld L, Nickenig G, Deuschl F, et al. Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study. Lancet 2017; 390(10096): 773–80
  18. Siminiak T, Wu JC, Haude M, Hoppe UC, Sadowski J, Lipiecki J, et al. Treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the TITAN Trial. Eur J Heart Fail 2012; 14(8): 931–8
  19. Lipiecki J, Siminiak T, Sievert H, Muller-Ehmsen J, Degen H, Wu JC, et al. Coronary sinus-based percutaneous annuloplasty as treatment for functional mitral regurgitation: the TITAN II trial. Open Heart 2016; 3(2): e000411
  20. Maisano F, Taramasso M, Nickenig G, Hammerstingl C, Vahanian A, Messika-Zeitoun D, et al. Cardioband, a transcatheter surgical-like direct mitral valve annuloplasty system: early results of the feasibility trial. Eur Heart J 2016; 37(10): 817–25

 

PHARMAFORUM:
Anwendung von LIXIANA®: Antworten auf praxisrelevante Fragen (S. 48)

  1. De Caterina R et al. Adv Ther 2017; 34(3): 620–637
  2. Fachinformation LIXIANA®, Stand Juli 2017
  3. Xu H et al. J Am Heart Assoc 2016; 5: 1–9
  4. Bohula EA et al. Circulation 2016; 134: 24-36.
  5. Giugliano RP et al. N Engl J Med 2013; 369: 2093–2104
  6. Steffel J et al. J Am Coll Cardiol 2016; 68: 1169–1178
  7. Magnani G et al. Eur J Heart Fail 2016; 18: 1153–1161